Blar i forfatter "Kostovski, Emil"

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    • Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin 

      Kostovski, Emil; Dahm, Anders Erik A; Mowinckel, Marie-Christine; Stranda, Annicke; Skretting, Grethe; Østerud, Bjarne; Sandset, Per Morten; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-03)
      Study design: This is a double-blind, randomized, placebo-controlled cross-over study of melatonin in complete tetraplegia.<p> <p>Objectives: Tetraplegic patients have an increased risk of venous thrombosis despite prophylaxis, blunted variations in melatonin and altered circadian variation of several hemostatic markers. To examine whether melatonin could modify the regulation of hemostasis, we ...

    • Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation 

      Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten; Mowinckel, Marie-Christine; Skretting, Grethe; Østerud, Bjarne; Bertolucci, C; Iversen, Per Ole (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-07-09)
      <i>Study design</i>: Crossover double blind, randomized placebo-controlled trial.<p> <p><i>Objectives</i>: Circadian oscillators are located both in the brain and in peripheral organs. Melatonin, the main brain-derived hormone governing circadian variations, is highly associated with daylight patterns. However, in subjects with tetraplegia the melatonin levels are blunted. Here we studied peripheral ...